This Week in Neuroscience
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This Week in Neuroscience
A podcast about the nervous system.
Episodi recenti
63 episodi
TWiN 64: How the brain decides what we see
TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignori...
TWiN 63: Microbiome-targeted neurotherapy
TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial...
TWiN 62: Memories of bad food
TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to...
TWiN 61: Blood to the brain
TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the...
TWiN 60: You get the gist of it?
TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuit...
TWiN 59: AI co-scientist
Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelera...
TWiN 58: Tongue-dragging rescue behavior
TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to res...
TWiN 57: Repetitive injury, herpes, and Alzheimer's
TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer...
TWiN 56: Astrocytes help neurons remember
TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learni...
TWiN 55: A brain circuit for day/night balance
TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to p...
TWiN 54: How pregnancy transforms the brain
TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.
Hosts: Vincent Rac...
TWiN 53: Slowing time by cooling the brain
Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal st...
TWiN 52: Probiotic improves social behavior in children with ASD
Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social...
TWiN 51: Sensory processing dysfunction in autism spectrum disorders
TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse model...
TWiN 50: Neurological sequelae after COVID-19
TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in...
TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?
TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling vi...
TWiN 48: Traumatic brain injury and retroviruses
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.
Hosts: V...
TWiN 47: Walking after spinal cord injury
TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-sp...
TWiN 46: Neuronal activity promotes glioma progression
TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity tha...
TWiN 45: Acupuncture modulates the immune system
TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues...
TWiN 44: ADHD and persistent pain
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammator...
TWiN 43: Pavlovian opioid tolerance
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop throu...
TWiN 42: Therapeutic effects of psychedelic drugs
TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases...
TWiN 41: Alzheimer's and melanin-concentrating hormone
Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and...
TWiN 40: Dopamine organizes behavior's syllables
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure ac...
TWiN 39: Virus-like capsids trigger paraneoplastic disease
Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibo...
TWiN 38: Bacterial immunity heals sensory neurons
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.
Hosts: Vinc...
TWiN 37: Microglia at the crossroads
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often impl...
TWiN 36: Unbearable neurologists
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips...
TWiN 35: Neuromodulation in treatment-resistant depression
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that...
TWiN 34: Microglia vital after spinal cord injury
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.
TWiN 33: Viruses leaving the brain
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.
Hosts: Vi...
TWiN 32: Relearning how to move after stroke
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity t...
TWiN 31: HIV-1 co-receptor shapes window for memory linking
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.
Hosts: Vincent...
TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic for...
TWiN 29: Astrocytes close the critical period
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.
Ho...
TWiN 28: Oligodendrocyte performance enhancing exosomes
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial prot...
TWiN 27: Eyes wired to the auditory cortex
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical o...
TWiN 26: Immunological memory in the brain
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses.
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TWiN 25: Thanks for listening
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that p...