Two Scientists Walk Into a Bar
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Two Scientists Walk Into a Bar
From research on cancer vaccines to why we feel pain, scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool for "Two Scientists Walk Into a Bar." Subscribe below to catch each episode as it goes live.
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50 episodi
S6E05: Cells at Work
Cell therapy holds immense potential to transform the way we treat conditions in oncology, ophthalmology, autoimmune disorders, and a wide range of ot...
S6E04: The Power of Digital Twins
Digital twins are virtual models of real-world systems that have been gaining momentum as a powerful tool in drug discovery and development. We touche...
S6E03: New Frontiers in Cancer
Each season we discuss new, exciting breakthroughs in cancer research. With evolving technologies enhancing how we understand and target the underlyin...
S6E02: AI and the Quest for New Antibiotics
We published our first episode on the threat of antibiotic resistance in 2016, and nearly a decade later, it remains one of the world’s most pressing...
S6E01: Digging Deeper into Obesity
As we kick off season six, we’re diving deeper into one of our most popular topics from last season – our evolving understanding of obesity. In this e...
Season Six Teaser
Join Danielle Mandikian and Maria Wilson as they kick off season six of Two Scientists Walk Into A Bar. Hear what they’ve been up to in the past few m...
S5E09: AI and The Future of Medicine
Machine learning and generative AI are transforming the ways we live and work, but how do these tools fit into the landscape of drug discovery? In our...
S5E08: A Deep Dive into Drug Modalities
Small molecules, antibodies, gene therapies – there are so many types of medicines scientists can consider when developing a new treatment for a disea...
S5E07: Organoids: From Dish to Discovery
Did you know that scientists can grow three-dimensional, miniature versions of human organs in a dish? These tiny in vitro models, known as organoids,...
S5E06: Cancer Conversations: Early Detection and Potent Solutions
To defeat cancer, we need to understand it better. How does it grow? How do we detect it early? And most importantly, how do we treat it? In this epis...
S5E05: The Streets and Deets of Obesity
What drives metabolic conditions like obesity? In this special episode, co-host and cardiovascular disease expert Maria Wilson, gRED Executive Directo...
S5E04: Engineering Therapeutic Antibodies
Antibodies are proteins produced by our immune system that neutralize or help destroy abnormal cells and foreign agents, like bacteria and viruses. Ho...
S5E03: No Delivery, No Drug
Many health conditions require medicines that can be delivered to specific parts of the body. For instance, someone with asthma requires medication th...
S5E02: Seeing Clearly: The Past, Present and Future of Eye Treatment
Imagine the eyes as cameras, where the cornea acts as the lens and the retina as the film. As with a camera, if something goes wrong in the eye, it ne...
S5E01: Merging Minds and Machines: The Future of Drug Discovery
Computational approaches have revolutionized how we interpret data. With the advent of genomic sequencing, scientists can derive significant conclusio...
Season Five Teaser
Join Danielle Mandikian and Maria Wilson as they kick off season five of Two Scientists Walk Into a Bar. Hear about their recent lab adventures and en...
S4E08: Learning from Vaccines: Training our Immune System to Fight Cancer
When we consider how a vaccine works, we typically think about vaccines that prevent infectious disease like flu or measles. But another type, known a...
S4E07: Representation Matters: Inclusivity in Clinical Trials
Because disease outcomes and responses to treatment can vary across populations, clinical research must include patients who are racially, ethnically...
S4E06: It's Personal: Inclusive Research and Precision Medicine
Achieving the first complete sequence of a human genome via the Human Genome Project represents an incredible feat – but it’s just the tip of the iceb...
S4E05: Antibiotic Resistance: A Call to Arms
Bacteria – and their constant ability to rapidly evolve and adapt – represent a scientific challenge that’s equal parts fascinating and disconcerting....
S4E04: The Where and When of Alzheimer’s Disease
Understanding what happens in the brain is notoriously difficult, but scientists have made progress in the past few decades. For Alzheimer’s disease,...
S4E03: Take A Deep Breath: Treating Asthma
Taking a deep breath can seem like a simple process; however, for millions of people with asthma, inflammation of the airways could make it difficult...
S4E02: Demystifying MS: The Intersection Of Immunology And Neuroscience
Our understanding of what causes multiple sclerosis (MS) has transformed over the last few decades. While discoveries of the cell types involved in MS...
Meet The Hosts of Season Four
Two Scientists Walk Into A Bar is back for a fourth season with new hosts, Maria Wilson and Danielle Mandikian! Get to know the new hosts and preview...
S4E0: Studying the Symphony of Cells
Cells are the basic unit of life, with a remarkable ability to sense their environment, process information and adapt accordingly. With 37.2 trillion...
S3E06: From Fly Genetics to Human Aging: Insights into Regenerative Medicine
The biological mysteries of age-related diseases have intrigued scientists for decades. In recent years, our expansive knowledge of genetics, thanks t...
S3E05: Beyond Biomarkers: Calling All Data Scientists
In Season 1, we talked about using biomarkers and big data to match patients with the best treatment for their disease. In this episode, Jane sits dow...
S3E04: A Look Into the Eye
Our eyes are our windows to the world, but what happens when those windows start to fade or disappear? To understand how the eye works, scientists are...
S3E03: Cancer: When Cells Go Rogue
It’s easy to think of cancer as an invader to the body. But in reality, it’s simply the result of a few proofreading errors in DNA replication that oc...
S3E02: Fire in the Gut: IBD Explained
Last episode, Jane and colleagues unraveled the intricacies of the human microbiome. This week, Jane chats with Mary Keir, Senior Scientist, Biomarker...
S3E01: Unraveling the Microbiome
Our bodies are full of bacteria - pounds of them actually. We’re kicking off Season 3 with a closer look at the human microbiome and what happens when...
Season Three Teaser
Two Scientists Walk Into a Bar is back for a third season with host Jane Grogan chatting with scientists who are leading the charge to understand comp...
S2E08: Why You Should Study Immunology
So far this season we’ve talked about the immune system a lot – how immune cells communicate, traffic along connective tissue, and invasive tumors. Bu...
S2E07: The Therapeutic Window
Pharmacology is the study of how a medicine works in the body, which is a critical step in understanding what medicines people should be given, and at...
S2E06: The Polarizing World of Neurons
Neurons, the cells that make up our brain, are some of the most unique cells in our bodies. The complex nature of how they communicate leads to everyt...
S2E05: Why Cells Die
The lifecycle of a cell mirrors our own lives – cells live and die as we do. It would be easy to think of cell death, or apoptosis, as a negative acti...
S2E04: Viruses, Bacteria and How to Beat Them
Despite the best efforts of the human immune system, viruses and bacteria are constantly evolving to find new ways to breach our bodies’ natural defen...
S2E03: What’s in a Pill?
Chemistry is all around us – from the air we breathe, to the food we eat, to the medicine we take when we’re sick. And for the researchers working to...
S2E02: Proteins: Seeing is Believing
The world of proteins is a minuscule and elegant ballet. Recent advances in imaging techniques have given us unprecedented views into this microscopic...
S2E01: Connective Tissue: The Hidden Metropolis
If your body was a city, then connective tissue would be the infrastructure tying everything together. It’s a hidden universe that helps many types of...